Nitrosative stress and pathogenesis of insulin resistance

M Kaneki, N Shimizu, D Yamada… - Antioxidants & redox …, 2007 - liebertpub.com
Insulin resistance is a major causative factor for type 2 diabetes and is associated with
increased risk of cardiovascular disease. Despite intense investigation for a number of …

Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma

M Kakiuchi, T Nishizawa, H Ueda, K Gotoh, A Tanaka… - Nature …, 2014 - nature.com
Diffuse-type gastric carcinoma (DGC) is characterized by a highly malignant phenotype with
prominent infiltration and stromal induction. We performed whole-exome sequencing on 30 …

Helicobacter pylori Infection Enhances N-Methyl-N-nitrosourea-induced Stomach Carcinogenesis in the Mongolian Gerbil

A Sugiyama, F Maruta, T Ikeno, K Ishida, S Kawasaki… - Cancer Research, 1998 - AACR
No previous report has demonstrated the relationship between Helicobacter pylori (HP)
infection and gastric carcinogenesis in an experimental animal model. A total of 170 male …

A role for iNOS in fasting hyperglycemia and impaired insulin signaling in the liver of obese diabetic mice

M Fujimoto, N Shimizu, K Kunii, JAJ Martyn, K Ueki… - Diabetes, 2005 - Am Diabetes Assoc
Chronic inflammation has been postulated to play an important role in the pathogenesis of
insulin resistance. Inducible nitric oxide synthase (iNOS) has been implicated in many …

[HTML][HTML] New method of endoscopic full-thickness resection: a pilot study of non-exposed endoscopic wall-inversion surgery in an ex vivo porcine model

O Goto, T Mitsui, M Fujishiro, I Wada, N Shimizu, Y Seto… - Gastric Cancer, 2011 - Springer
The indications for endoscopic full-thickness resection (EFTR) are limited because
transmural communication during the entire procedure, causing tumor dissemination into the …

Effect of early eradication on Helicobacter pylori‐related gastric carcinogenesis in Mongolian gerbils

K Nozaki, N Shimizu, Y Ikehara, M Inoue… - Cancer …, 2003 - Wiley Online Library
Helicobacter pylori (Hp) infection and gastric carcinogenesis are known to have a close
relationship, but the effect of eradication of Hp on Hp‐related gastric carcinogenesis has not …

Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65

S Shinozaki, K Chang, M Sakai, N Shimizu… - Science …, 2014 - science.org
Inflammation increases the abundance of inducible nitric oxide synthase (iNOS), leading to
enhanced production of nitric oxide (NO), which can modify proteins by S-nitrosylation …

Fractional calculus approach to dynamic problems of viscoelastic materials

N Shimizu, W Zhang - … journal series C mechanical systems, machine …, 1999 - jstage.jst.go.jp
抄録 This article presents a review on the application of the fractional calculus to
viscoelasticity. There are several methods to treat viscoelasticity of viscoelastic materials …

Peppermint oil reduces gastric spasm during upper endoscopy: a randomized, double-blind, double-dummy controlled trial

N Hiki, H Kurosaka, Y Tatsutomi, S Shimoyama… - Gastrointestinal …, 2003 - Elsevier
Background: Gl endoscopy without general anesthesia causes a hyperperistaltic state in the
stomach, which frequently necessitates the use of antispasmodic agents, such as hyoscine …

[HTML][HTML] Visualization and exploration of Tcf/Lef function using a highly responsive Wnt/β-catenin signaling-reporter transgenic zebrafish

N Shimizu, K Kawakami, T Ishitani - Developmental biology, 2012 - Elsevier
Evolutionarily conserved Tcf/Lef transcription factors (Lef1, Tcf7, Tcf7l1, and Tcf7l2) mediate
gene expression regulated by Wnt/β-catenin signaling, which has multiple roles in early …