User profiles for "author:Peter Caravan"
Peter CaravanMartinos Center for Biomedical Imaging, Institute for Innovation in Imaging (i3), MGH … Verified email at nmr.mgh.harvard.edu Cited by 25210 |
[PDF][PDF] Gadolinium (III) chelates as MRI contrast agents: structure, dynamics, and applications
P Caravan, JJ Ellison, TJ McMurry… - Chemical reviews, 1999 - mriquestions.com
Gadolinium, an obscure lanthanide element buried in the middle of the periodic table, has in
the course of a decade become commonplace in medical diagnostics. Like platinum in …
the course of a decade become commonplace in medical diagnostics. Like platinum in …
Chemistry of MRI contrast agents: current challenges and new frontiers
Tens of millions of contrast-enhanced magnetic resonance imaging (MRI) exams are
performed annually around the world. The contrast agents, which improve diagnostic …
performed annually around the world. The contrast agents, which improve diagnostic …
Strategies for increasing the sensitivity of gadolinium based MRI contrast agents
P Caravan - Chemical Society Reviews, 2006 - pubs.rsc.org
Gadolinium (III) complexes are often used in clinical MRI to increase contrast by selectively
relaxing the water molecules near the complex. There is a desire to improve the sensitivity …
relaxing the water molecules near the complex. There is a desire to improve the sensitivity …
The interaction of MS-325 with human serum albumin and its effect on proton relaxation rates
P Caravan, NJ Cloutier, MT Greenfield… - Journal of the …, 2002 - ACS Publications
MS-325 is a novel blood pool contrast agent for magnetic resonance imaging currently
undergoing clinical trials to assess blockage in arteries. MS-325 functions by binding to …
undergoing clinical trials to assess blockage in arteries. MS-325 functions by binding to …
Biodistribution of gadolinium‐based contrast agents, including gadolinium deposition
The biodistribution of approved gadolinium (Gd)‐based contrast agents (GBCAs) is
reviewed. After intravenous injection GBCAs distribute in the blood and the extracellular …
reviewed. After intravenous injection GBCAs distribute in the blood and the extracellular …
Influence of molecular parameters and increasing magnetic field strength on relaxivity of gadolinium‐ and manganese‐based T1 contrast agents
Simulations were performed to understand the relative contributions of molecular
parameters to longitudinal (r1) and transverse (r2) relaxivity as a function of applied field …
parameters to longitudinal (r1) and transverse (r2) relaxivity as a function of applied field …
Primer on gadolinium chemistry
Gadolinium is widely known by all practitioners of magnetic resonance imaging (MRI) but
few appreciate the basic solution chemistry of this trivalent lanthanide ion. Given the recent …
few appreciate the basic solution chemistry of this trivalent lanthanide ion. Given the recent …
Protein-targeted gadolinium-based magnetic resonance imaging (MRI) contrast agents: design and mechanism of action
P Caravan - Accounts of chemical research, 2009 - ACS Publications
Magnetic resonance imaging (MRI) is a powerful medical diagnostic technique: it can
penetrate deep into tissue, provide excellent soft tissue contrast with sub-millimeter …
penetrate deep into tissue, provide excellent soft tissue contrast with sub-millimeter …
A manganese alternative to gadolinium for MRI contrast
Contrast-enhanced computed tomography (CT) and magnetic resonance imaging (MRI) are
routinely used to diagnose soft tissue and vascular abnormalities. However, safety concerns …
routinely used to diagnose soft tissue and vascular abnormalities. However, safety concerns …
[PDF][PDF] Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the most rapidly increasing cause of cancer‐related
mortality in the United States. Because of the lack of viable treatment options for HCC …
mortality in the United States. Because of the lack of viable treatment options for HCC …