User profiles for "author:Peter Caravan"

Peter Caravan

Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging (i3), MGH …
Verified email at nmr.mgh.harvard.edu
Cited by 25210

[PDF][PDF] Gadolinium (III) chelates as MRI contrast agents: structure, dynamics, and applications

P Caravan, JJ Ellison, TJ McMurry… - Chemical reviews, 1999 - mriquestions.com
Gadolinium, an obscure lanthanide element buried in the middle of the periodic table, has in
the course of a decade become commonplace in medical diagnostics. Like platinum in …

Chemistry of MRI contrast agents: current challenges and new frontiers

J Wahsner, EM Gale, A Rodríguez-Rodríguez… - Chemical …, 2018 - ACS Publications
Tens of millions of contrast-enhanced magnetic resonance imaging (MRI) exams are
performed annually around the world. The contrast agents, which improve diagnostic …

Strategies for increasing the sensitivity of gadolinium based MRI contrast agents

P Caravan - Chemical Society Reviews, 2006 - pubs.rsc.org
Gadolinium (III) complexes are often used in clinical MRI to increase contrast by selectively
relaxing the water molecules near the complex. There is a desire to improve the sensitivity …

The interaction of MS-325 with human serum albumin and its effect on proton relaxation rates

P Caravan, NJ Cloutier, MT Greenfield… - Journal of the …, 2002 - ACS Publications
MS-325 is a novel blood pool contrast agent for magnetic resonance imaging currently
undergoing clinical trials to assess blockage in arteries. MS-325 functions by binding to …

Biodistribution of gadolinium‐based contrast agents, including gadolinium deposition

S Aime, P Caravan - … Resonance Imaging: An Official Journal of …, 2009 - Wiley Online Library
The biodistribution of approved gadolinium (Gd)‐based contrast agents (GBCAs) is
reviewed. After intravenous injection GBCAs distribute in the blood and the extracellular …

Influence of molecular parameters and increasing magnetic field strength on relaxivity of gadolinium‐ and manganese‐based T1 contrast agents

P Caravan, CT Farrar, L Frullano… - Contrast media & …, 2009 - Wiley Online Library
Simulations were performed to understand the relative contributions of molecular
parameters to longitudinal (r1) and transverse (r2) relaxivity as a function of applied field …

Primer on gadolinium chemistry

AD Sherry, P Caravan… - Journal of magnetic …, 2009 - Wiley Online Library
Gadolinium is widely known by all practitioners of magnetic resonance imaging (MRI) but
few appreciate the basic solution chemistry of this trivalent lanthanide ion. Given the recent …

Protein-targeted gadolinium-based magnetic resonance imaging (MRI) contrast agents: design and mechanism of action

P Caravan - Accounts of chemical research, 2009 - ACS Publications
Magnetic resonance imaging (MRI) is a powerful medical diagnostic technique: it can
penetrate deep into tissue, provide excellent soft tissue contrast with sub-millimeter …

A manganese alternative to gadolinium for MRI contrast

EM Gale, IP Atanasova, F Blasi, I Ay… - Journal of the American …, 2015 - ACS Publications
Contrast-enhanced computed tomography (CT) and magnetic resonance imaging (MRI) are
routinely used to diagnose soft tissue and vascular abnormalities. However, safety concerns …

[PDF][PDF] Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma

BC Fuchs, Y Hoshida, T Fujii, L Wei, S Yamada… - …, 2014 - Wiley Online Library
Hepatocellular carcinoma (HCC) is the most rapidly increasing cause of cancer‐related
mortality in the United States. Because of the lack of viable treatment options for HCC …