Background Stroke thrombolysis with alteplase is currently recommended 0–4· 5 h after
stroke onset. We aimed to determine whether perfusion imaging can identify patients with …

Background—Thrombolysis is the treatment of choice for acute stroke within 3 hours after
symptom onset. Treatment beyond the 3-hour time window has not been shown to be …

Background and Purpose—The diversity of available outcome measures for acute stroke
trials is challenging and implies that the scales may be imperfect. To assist researchers …

Background Mechanical thrombectomy (MT) has become the cornerstone of acute ischemic
stroke management in patients with large vessel occlusion (LVO). Objective To assist …

Background and Purpose—Numerous preclinical findings and a clinical pilot study suggest
that recombinant human erythropoietin (EPO) provides neuroprotection that may be …

Background Cryptogenic strokes constitute 20 to 30% of ischemic strokes, and most
cryptogenic strokes are considered to be embolic and of undetermined source. An earlier …

Importance Although use of oral anticoagulants (OACs) is increasing, there is a substantial
lack of data on how to treat OAC-associated intracerebral hemorrhage (ICH). Objective To …

Background and Purpose—Moderate hypothermia decreases ischemic damage in
experimental stroke models. This multicenter study was performed to evaluate (1) the safety …

Background and Purpose—Although modern multisequence stroke MRI protocols are an
emerging imaging routine for the diagnostic assessment of acute ischemic stroke, their …

Background and Purpose—We investigated whether transient ischemic attacks (TIAs) before
stroke can induce tolerance by raising the threshold of tissue vulnerability in the human …