Efficacy of bilateral prophylactic mastectomy in BRCA1 and BRCA2 gene mutation carriers
LC Hartmann, TA Sellers, DJ Schaid… - Journal of the …, 2001 - academic.oup.com
Background: In women with a family history of breast cancer, bilateral prophylactic
mastectomy is associated with a decreased risk of subsequent breast cancer of …
mastectomy is associated with a decreased risk of subsequent breast cancer of …
Clinical Characteristics of Individuals With Germline Mutations in BRCA1 and BRCA2: Analysis of 10,000 Individuals
TS Frank, AM Deffenbaugh, JE Reid… - Journal of Clinical …, 2002 - ascopubs.org
PURPOSE: To assess the characteristics that correlate best with the presence of mutations
in BRCA1 and BRCA2 in individuals tested in a clinical setting. PATIENTS AND METHODS …
in BRCA1 and BRCA2 in individuals tested in a clinical setting. PATIENTS AND METHODS …
Sequence analysis of BRCA1 and BRCA2: correlation of mutations with family history and ovarian cancer risk.
TS Frank, SA Manley, OI Olopade… - Journal of Clinical …, 1998 - ascopubs.org
PURPOSE Previous studies of mutations in BRCA1 or BRCA2 have used detection methods
that may underestimate the actual frequency of mutations and have analyzed women using …
that may underestimate the actual frequency of mutations and have analyzed women using …
BRCA1 sequence analysis in women at high risk for susceptibility mutations: risk factor analysis and implications for genetic testing
D Shattuck-Eidens, A Oliphant, M McClure, C McBride… - Jama, 1997 - jamanetwork.com
Octext.—A mutation in theBRCA1gene may confer substantial risk for breast and/or ovarian
cancer. However, knowledge regarding all possible mutations and the relationship between …
cancer. However, knowledge regarding all possible mutations and the relationship between …
Somatic mutations in the BRCA1 gene in sporadic ovarian tumours
The BRCA1 gene on chromosome 17q21 is responsible for an autosomal dominant
syndrome of increased susceptibility to breast and ovarian cancer but no somatic mutations …
syndrome of increased susceptibility to breast and ovarian cancer but no somatic mutations …
Differential isolation of normal luminal mammary epithelial cells and breast cancer cells from primary and metastatic sites using selective media
SP Ethier, ML Mahacek, WJ Gullick, TS Frank… - Cancer research, 1993 - AACR
The present studies were aimed at determining if the use of a cell culture medium that
supports proliferation of human mammary epithelial cells of the luminal lineage would allow …
supports proliferation of human mammary epithelial cells of the luminal lineage would allow …
Clinical and pathological significance of microsatellite instability in sporadic endometrial carcinoma.
RF Caduff, CM Johnston… - The American journal …, 1996 - ncbi.nlm.nih.gov
Defective DNA mismatch repair in neoplasia is manifested by extra, aberrant bands within
multiple microsatellite markers. The replication error (RER) phenotype is present in most …
multiple microsatellite markers. The replication error (RER) phenotype is present in most …
Hereditary cancer syndromes
TS Frank - Archives of pathology & laboratory medicine, 2001 - meridian.allenpress.com
Objective.—To summarize the biological basis, clinical implications, identification, and
medical management of syndromes associated with increased risk of common adult …
medical management of syndromes associated with increased risk of common adult …
Germline BRCA1 mutations and loss of the wild-type allele in tumors from families with early onset breast and ovarian cancer.
SD Merajver, TS Frank, J Xu, TM Pham… - Clinical cancer research …, 1995 - AACR
The BRCA1 gene on human chromosome 17q21 is responsible for an autosomal dominant
syndrome of inherited early onset breast/ovarian cancer. It is estimated that women …
syndrome of inherited early onset breast/ovarian cancer. It is estimated that women …
Paget disease of the nipple: radiologic-pathologic correlation.
DM Ikeda, MA Helvie, TS Frank, KL Chapel… - Radiology, 1993 - pubs.rsna.org
PURPOSE: To correlate the range of clinical presentations with mammographic and
histologic findings in patients with Paget disease of the nipple. MATERIALS AND …
histologic findings in patients with Paget disease of the nipple. MATERIALS AND …