Effector CD4+ T cells, the cytokines they generate, and GVHD: something old and something new

JM Coghill, S Sarantopoulos, TP Moran… - Blood, The Journal …, 2011 - ashpublications.org
GVHD is a syndrome that results from minor and major histocompatibility complex
incompatibilities between the donor and recipient. More than 50 years after its initial …

The airway as a route of sensitization to peanut: An update to the dual allergen exposure hypothesis

MD Kulis, JM Smeekens, RM Immormino… - Journal of Allergy and …, 2021 - Elsevier
Food allergies have increased at an alarming rate over the past 2 decades, indicating that
environmental factors are driving disease progression. It has been postulated that …

The mode of action of Shiga toxin on peptide elongation of eukaryotic protein synthesis

TG Obrig, TP Moran, JE Brown - Biochemical Journal, 1987 - portlandpress.com
The effect of Shiga toxin, from Shigella dysenteriae 1, on the component reactions of peptide
elongation were investigated. Enzymic binding of [3H] phenylalanine-tRNA to reticulocyte …

The external exposome and food allergy

TP Moran - Current allergy and asthma reports, 2020 - Springer
Abstract Purpose of Review The recent increase in childhood food allergy prevalence
strongly suggests that environmental exposures are contributing to food allergy …

Metabolite profiling reveals the glutathione biosynthetic pathway as a therapeutic target in triple-negative breast cancer

A Beatty, LS Fink, T Singh, A Strigun, E Peter… - Molecular cancer …, 2018 - AACR
Cancer cells can exhibit altered dependency on specific metabolic pathways and targeting
these dependencies is a promising therapeutic strategy. Triple-negative breast cancer …

Indoor dust acts as an adjuvant to promote sensitization to peanut through the airway

JM Smeekens, RM Immormino… - Clinical & …, 2019 - Wiley Online Library
Background There is growing evidence that environmental peanut exposure through non‐
oral routes, including the skin and respiratory tract, can result in peanut sensitization …

Complement receptor C5aR1/CD88 and dipeptidyl peptidase-4/CD26 define distinct hematopoietic lineages of dendritic cells

H Nakano, TP Moran, K Nakano, KE Gerrish… - The Journal of …, 2015 - journals.aai.org
Differential display of the integrins CD103 and CD11b are widely used to distinguish two
major dendritic cell (DC) subsets in nonlymphoid tissues. CD103+ DCs arise from FLT3 …

[HTML][HTML] Fecal IgA, antigen absorption, and gut microbiome composition are associated with food antigen sensitization in genetically susceptible mice

JM Smeekens, BT Johnson-Weaver, AL Hinton… - Frontiers in …, 2021 - frontiersin.org
Food allergy is a potentially fatal disease affecting 8% of children and has become
increasingly common in the past two decades. Despite the prevalence and severe nature of …

[HTML][HTML] TNF is required for TLR ligand–mediated but not protease-mediated allergic airway inflammation

GS Whitehead, SY Thomas… - The Journal of …, 2017 - Am Soc Clin Investig
Asthma is associated with exposure to a wide variety of allergens and adjuvants. The extent
to which overlap exists between the cellular and molecular mechanisms triggered by these …

Neuropilin-2 regulates airway inflammatory responses to inhaled lipopolysaccharide

RM Immormino, DC Lauzier… - … of Physiology-Lung …, 2018 - journals.physiology.org
Neuropilins are multifunctional receptors that play important roles in immune regulation.
Neuropilin-2 (NRP2) is expressed in the lungs, but whether it regulates airway immune …