▪ Abstract Precise regulation of major histocompatibility complex class II (MHC-II) gene
expression plays a crucial role in the control of the immune response. A major breakthrough …

The bare lymphocyte syndrome (BLS) is a hereditary immunodeficiency resulting from the
absence of major istocompatibility complex class II (MHCII) expression. Considering the …

MHC class II molecules are pivotal for the adaptive immune system, because they guide the
development and activation of CD4+ T helper cells. Fulfilling these functions requires that …

Conditional mutagenesis in mice has recently been made possible through the combination
of gene targeting techniques and site–directed mutagenesis, using the bacteriophage P1 …

Immune regulatory proteins such as CIITA, NAIP, IPAF, NOD1, NOD2, NALP1, and cryopyrin
(also known as NALP3) are members of a family characterized by the presence of a NACHT …

In response to inflammatory stimulation, dendritic cells (DCs) have a remarkable pattern of
differentiation (maturation) that exhibits specific mechanisms to control immunity. Here, we …

BACKGROUND AND PURPOSE: Data from recent reports have indicated that mechanical
thrombectomy may have potential as a treatment for acute ischemic stroke. The purpose of …

Summary Background Only 2–5% of patients who have a stroke receive thrombolytic
treatment, mainly because of delay in reaching the hospital. We aimed to assess the efficacy …

Inflammatory CD4+ T cell responses to self or commensal bacteria underlie the
pathogenesis of autoimmunity and inflammatory bowel disease (IBD), respectively. Although …

Background and Purpose—The purpose of this study was to demonstrate a new approach to
the use of a self-expanding stent in the treatment of acute ischemic stroke. Methods—Twenty …