Background Among patients with a proximal vessel occlusion in the anterior circulation, 60
to 80% of patients die within 90 days after stroke onset or do not regain functional …

Importance Endovascular thrombectomy with second-generation devices is beneficial for
patients with ischemic stroke due to intracranial large-vessel occlusions. Delineation of the …

Background Nerinetide, an eicosapeptide that interferes with post-synaptic density protein
95, is a neuroprotectant that is effective in preclinical stroke models of ischaemia-reperfusion. …

Background— The Endovascular Treatment for Small Core and Proximal Occlusion Ischemic
Stroke (ESCAPE) trial used innovative imaging and aggressive target time metrics to …

Background Tandem occlusions of the extracranial carotid and intracranial carotid or middle
cerebral artery have a particularly poor prognosis without treatment. Several management …

Recent landmark randomized controlled trial data 1–7 have initiated a global transformational
change in acute stroke therapy for ischemic stroke patients with large vessel occlusion. …

Importance The benefits of endovascular thrombectomy (EVT) are time dependent. Prior
studies may have underestimated the time-benefit association because time of onset is …

BACKGROUND AND IMPORTANCE: Intracranial venous hypertension is known to be
associated with venous outflow obstruction. We discuss the diagnosis and treatment of …

BACKGROUND Ischemic stroke is a leading cause of death and disability worldwide. Much
of the long-term disability occurs in patients with Emergent Large Vessel Occlusion (ELVO). …

Background and Purpose— Infarct in a new previously unaffected territory (INT) is a potential
complication of endovascular treatment. We applied a recently proposed methodology to …