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  • Aneurysms of the communicating segment of the internal carotid artery with posterior communicating artery agenesis are associated with perforator infarction after embolization

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Hemorrhagic stroke
Original research
Aneurysms of the communicating segment of the internal carotid artery with posterior communicating artery agenesis are associated with perforator infarction after embolization
  1. Davide Simonato1,
  2. Sergios Gargalas1,
  3. Pete J Cox1,
  4. Victoria Young1,
  5. Rufus Corkill1,
  6. Wilhelm Kuker1,2,
  7. Maurizio Fuschi1,
  8. Emmanuel Houdart3,
  9. Marc-Antoine Labeyrie3
  1. 1 Neuroradiology, Oxford University Hospitals NHS Foundation Trust, Oxford, Oxfordshire, UK
  2. 2 Nuffield Department of Clinical Neurosciences, Oxford Brookes University Faculty of Health and Life Sciences, Oxford, UK
  3. 3 Interventional Neuroradiology, Groupe hospitalier Lariboisiere Fernand-Widal, Université de Paris, Paris, France
  1. Correspondence to Dr Marc-Antoine Labeyrie, Neuroradiology, Groupe hospitalier Lariboisiere Fernand-Widal, 75010 Paris, Île-de-France, France; marc-antoine.labeyrie{at}aphp.fr

Abstract

Background While anatomic features associated with the risk of posterior communicating artery (PcoA) occlusion after embolization of aneurysms of the PcoA segment of the internal carotid artery (ICA) are well known, the link between perforator origin and perforator infarction has only been reported following neurosurgical clipping. The aim of this study was to determine the origin of anterior thalamic perforators and correlate it with risk of perforator infarction after embolization of PcoA segment aneurysms.

Methods One-hundred-and-ninety consecutive patients treated for PcoA segment aneurysms between 2017 and 2019 were included. PcoA and anterior thalamic perforator origin anatomy was assessed with computed tomography (CT) angiography, digital subtracted angiography, and high-resolution three-dimensional rotational cone-beam CT angiography (CBCT-A) by two independent interventional neuroradiologists. The presence of perforator infarction after embolization was ascertained from the patient’s notes and follow-up imaging.

Results CBCT-A was superior in demonstrating the origin of perforators (P<0.001). The prevalence of perforator origin was estimated at 86% (95% CI 81%–92%) for PcoA, 8% (95% CI 4%–13%) for aneurysm wall, and 5% (95% CI 2%–9%) for ICA. The aneurysm wall origin was exclusively associated with PcoA agenesis, as well as higher risk of perforator infarction after aneurysm coiling compared with other variants (OR=14, 95% CI 2–88, P=0.006).

Conclusions Our study suggests that anterior thalamic perforators may arise from aneurysm wall when there is no PcoA. Anatomic association between PcoA agenesis and perforator arising from ICA could underlie such findings, and careful consideration is essential before aneurysm repair to anticipate the risk of thalamic infarction in such cases.

  • aneurysm
  • embolic
  • angiography
  • complication

https://doi.org/10.1136/neurintsurg-2020-016083

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    Footnotes

    • Contributors Substantial contributions to the conception or design of the work: DS, M-AL. Acquisition, analysis, or interpretation of data for the work: DS, M-AL. Drafting the work: DS, SG. Revising it critically for important intellectual content: MF, PJC, VY, WK, RC. Final approval of the version to be published: EH, WK, M-AL. Agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved: all authors.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Patient consent for publication Not required.

    • Ethics approval The study complied with the authors' local ethics committee rules and was registered as Audit No. 5794 (Oxford University Hospitals NHS Trust) and 135 729 (Assistance Publique Hopitaux de Paris).

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Data availability statement Data are available upon reasonable request. Deidentified participant data are available from Marc-Antoine Labeyrie (marc-antoine.labeyrie@aphp.fr). Statistical analysis plans are also available.