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Case series
Natural history of brain capillary vascular malformations in hereditary hemorrhagic telangiectasia patients
  1. Waleed Brinjikji1,
  2. Vivek N Iyer2,
  3. Giuseppe Lanzino3,
  4. Kent R Thielen1,
  5. Christopher P Wood1
  1. 1Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA
  2. 2Department of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota, USA
  3. 3Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota, USA
  1. Correspondence to Dr W Brinjikji, Department of Radiology, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA; Brinjikji.waleed{at}mayo.edu

Abstract

Background and purpose Brain capillary vascular malformations (CVMs) are known to occur with relatively high frequency in hereditary hemorrhagic telangiectasia (HHT) patients. These lesions are thought to have a benign natural history but this has not been systematically studied. The purpose of our study was to examine the natural history of CVMs in a consecutive series of HHT patients.

Materials and methods Consecutive patients with untreated CVMs receiving serial imaging were included. Baseline data including demographics, HHT gene mutations, and Curacao diagnostic criteria were collected. The primary outcome was rupture on follow-up. A secondary outcome was new focal neurological deficit or seizure related to the lesion.

Results 22 patients with 42 CVMs were included. Mean age was 45.9±16.9 years. 18 patients (81.8%) were women and 4 (18.2%) were men. 19 patients (86.4%) had definite HHT and 3 patients (13.6%) had probable HHT. Mean follow-up was 4.6±3.7 years. There were a total of 100.2 patient years of follow-up and 222.5 lesion years. No lesions ruptured on follow-up and no patient had focal neurological deficits or seizures related to the lesions.

Conclusions Our study found that CVMs in HHT patients have a benign natural history as no patients had hemorrhage or other symptoms related to these lesions. These findings should be confirmed in additional multicenter longitudinal studies.

  • Arteriovenous Malformation
  • Hemorrhage
  • Genetic

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Footnotes

  • Contributors CPW, WB, KRT, VNI, and GL participated in drafting the article and revising it critically for important intellectual content. These authors made substantial contributions to conception and design, acquisition of the data, and analysis and interpretation of the data. All authors provided final approval of the version to be published.

  • Competing interests None declared.

  • Ethics approval The study was approved by the Mayo Clinic institutional review board.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement The authors are willing to share deidentified data following institutional review board approval at both institutions.

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