You are here

  • Home
  • Online First
  • Effects of calcium channel blockers on perioperative ischemic events in hypertensive patients with intracranial aneurysms undergoing neurointervention

Article Text

Article menu
Download PDFPDF
Hemorrhagic stroke
Original research
Effects of calcium channel blockers on perioperative ischemic events in hypertensive patients with intracranial aneurysms undergoing neurointervention
  1. Qichen Peng1,2,
  2. Yangyang Zhou1,2,
  3. Chao Wang1,2,
  4. Xuanping Xie1,2,
  5. Linggen Dong1,2,
  6. Yisen Zhang1,2,
  7. Hongqi Zhang3,
  8. Jun Wang4,
  9. Liang Li5,
  10. Pinyuan Zhang6,
  11. Yuanli Zhao7,
  12. Yang Wang8,
  13. Fushun Xiao9,
  14. Bin Luo10,
  15. Wenqiang Li1,2,
  16. Shiqing Mu1,2
  1. 1Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China
  2. 2Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
  3. 3Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing, China
  4. 4Department of Neurology, Chinese PLA General Hospital, Beijing, Beijing, China
  5. 5Department of Neurosurgery, Peking University First Hospital, Beijing, Beijing, China
  6. 6Department of Neurosurgery, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China
  7. 7Department of Neurosurgery, Peking Union Medical College Hospital, Beijing, China
  8. 8Department of Neurosurgery, Beijing Chaoyang Hospital, Beijing, Beijing, China
  9. 9Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China
  10. 10Department of Neurosurgery, Peking University International Hospital, Beijing, China
  1. Correspondence to Dr Shiqing Mu, Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100070, China; mu_sq1216{at}163.com; Dr Wenqiang Li, Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China; lwqsurgeon{at}163.com

Abstract

Background Although calcium channel blockers (CCBs) are useful in stroke prevention, their specific role in preventing stroke in hypertensive patients with intracranial aneurysms undergoing endovascular stent placement remains unclear.

Methods We retrospectively examined 458 hypertensive patients with intracranial aneurysms who underwent stent treatment, drawn from a larger multicenter cohort comprising 1326 patients across eight centers. Patients were dichotomized into two groups according to use of a CCB. Propensity score matching (PSM) was performed to balance group differences in patient and aneurysm characteristics. We conducted a comparison of patient and aneurysm characteristics, ischemic complications, and clinical outcomes between the two groups.

Results The CCB and non-CCB groups comprised 279 and 179 patients, respectively. PSM resulted in 165 matched pairs. After PSM, the incidence of ischemic events within 1 month of the procedure (4.2% vs 10.9%; P=0.022) and proportion of patients with modified Rankin Scale score >2 at last follow-up (1.5% vs 7.8%; P=0.013) were significantly lower in the CCB group. Among patients treated with combination therapy, inclusion of a CCB was associated with a lower incidence of ischemic events (1.5% vs 13.3%; P=0.345), but the difference was not statistically significant after correction.

Conclusions CCB use in hypertensive patients undergoing endovascular stenting for treatment of intracranial aneurysms is associated with a lower incidence of ischemic events and a lower incidence of unfavorable neurological outcomes, especially when used in combination therapy.

  • Aneurysm
  • Stroke
  • Stent
  • Drug

Data availability statement

Data are available upon reasonable request.

https://doi.org/10.1136/jnis-2024-021543

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Data availability statement

    Data are available upon reasonable request.

    View Full Text

    Footnotes

    • QP and YZ contributed equally.

    • WL and SM contributed equally.

    • Contributors QP and YZhou collected most of the clinical data and wrote the manuscript. CW, XX, LD and YZhang helped to collect the clinical data. YZhang and BL reviewed the imaging data. HZ, JW, LL, PZ, YZhao, YW and FX critically revised the manuscript for important intellectual content. SM and WL designed the research, helped to revise the manuscript, and handled the funding and supervision. SM and WL are guarantors for the paper. All authors read and approved the final manuscript.

    • Funding This work was supported by the National Natural Science Foundation of China (grant number: 82371315), Capital’s Funds for Health Improvement and Research (grant number: 2022–1-2041), National Health Commission of the People’s Republic of China (grant number: GWJJ2022100104) and Summit Talent Program (grant number: DFL20220504).

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.